What is Turmeric?
Curcuma longa, also known as turmeric, has been documented since the seventh century AD in Chinese and Indian medicine for its healing properties. It has been used for a multitude of ailments that range from cancer, flatulence, jaundice, hematuria, inflammation, and bacterial infections. It is a member of the Zingiberaceae family and is grown extensively through Asia, India, China, and other tropical climates. The rhizome is the part that is medicinally used and is prepared using a process of boiling, cleaning, and drying. The active constituents of Curcuma are the flavonoids and volatile oils. The curcumin flavonoids, also known as curcumin, demethoxycurcumin, and bis-demethoxycurcumin give curcuma its bright yellow color and are becoming more extensively studied for their oncological effects.

What is the research showing about Turmeric?
Research is showing that Curcuma contains the properties of an antioxidant, prevent lipid (fat) oxidation in the arteries that causes plaquing, protective to the liver, anti-inflammatory, and anti-carcinogenic via inhibiting tumor growth, promotion, angiogenesis, and latering tumor gene expression. These multiple properties allow Curcuma to affect tumor cells via various pathways, an advantageous system as tumor cells are known to escape host defense mechanisms using multiple means.Curcuma has been shown to suppress proliferation of tumor cells within multiple lines of cancer. This list includes but is not limited to: breast carcinoma, colon carcinoma, renal cell carcinoma, hepatocellular carcinoma, T cell leukemia, B cell lymphoma, acute myelogenous leukemia, basal cell carcinoma, melanoma, and prostate carcinoma. It has been well documented that Curcuma inhibits tumor cell proliferation via inhibiting the transcription factor nuclear factor kappaB (NF-kappaB). NF-kappaB mediates cell survival and proliferation, allowing tumor cells to evade apoptosis (cell death) with activation. Because of Curcuma’s ability to inhibit the specific transcription factor (part of the genetic machinery that is important for cellular replication), it is being studied  as a chemosensatizing agent. One study found that concomitant Curcuma use increased drug induced tumor cell death with the chemotherapy durgs 5-fluorouracil and cisplatin.

 

Can I take any Turmeric Supplement?
The quality, purity, and bioavailability of supplements in the nutraceutical market vary widely upon the manufacturers. For this reason, it is imperative that the nutraceutical companies have strict quality control. If you doubt what companies are good, give the office a call.

 

 

info@nawellness.com • 310-926-4415

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2) Curcumin Induces the Differentiation of Myeloid-Derived Suppressor  Cells and Inhibits Their Interaction with Cancer Cells and Related Tumor Growth. Cancer Prev Res (Phila). 2011 Nov 23. Proc Nutr Soc.
3) Nutritional influences on epigenetics and age-related disease.Proc Nutr Soc. 2011 Nov 4:1-9.
4) Effect on pro-inflammatory and antioxidant genes and bioavailable distribution of whole turmeric vs curcumin: Similar root but different effects. 2011 Nov 4:1-9.Food Chem Toxicol. 2011 Nov 4
5) Curcumin induces Apaf-1 dependent, p21-mediated caspase activation and apoptosis. Cell Cycle. 2011 Dec 1;10(23).
6) Curcumin analog CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res. 2011 Nov 22
7) Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I–III from Curcuma longa. PhytomedicineVolume 7, Issue 4, July 2000, Pages 303-308
8) The anti-oxidant activity of turmeric. Journal of EthnopharmacologyVolume 47, Issue 2, 7 July 1995, Pages 59-67